Stem Cell Therapies Benefit Alport Syndrome
نویسندگان
چکیده
منابع مشابه
Stem cell therapies benefit Alport syndrome.
Patients with Alport syndrome progressively lose renal function as a result of defective type IV collagen in their glomerular basement membrane. In mice lacking the alpha3 chain of type IV collagen (Col4A3 knockout mice), a model for Alport syndrome, transplantation of wild-type bone marrow repairs the renal disease. It is unknown whether cell-based therapies that do not require transplantation...
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A.K. was a 5-year-old boy who presented to the pediatric nephrology clinic with a recent finding of microscopic hematuria and proteinuria on routine screening. The analysis was repeated two weeks later with persistence of hematuria and proteinuria. A complete blood count (CBC) and a metabolic panel (Chem7) were both normal. Renal ultrasound was performed which was also normal and without hydron...
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Gross, O; Borza, D B ; Andres, H J; Licht, C; Weber, M; Segerer, S; Torra, R; Gubler, M C; Heidet, L; Harvey, S; Cosgrove, D; Lees, G; Kashtan, C; Gregory, M; Savige, J; Ding, J; Thorner, P; Abrahamson, D R ; Antignac, C; Tryggvason, K ; Hudson, B; Miner, J H Gross, O; Borza, D B; Andres, H J; Licht, C; Weber, M; Segerer, S; Torra, R; Gubler, M C; Heidet, L; Harvey, S; Cosgrove, D; Lees, G; Kas...
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1Department of Nephrology & Rheumatology, University of Göttingen, Göttingen, Germany, 2Department of Medicine, Division of Nephrology, Vanderbilt University Medical Center, Nashville, TN, USA, 3Department of Nephrology, Medical Policlinic, University of Munich, Munich, Germany, 4Division of Nephrology, The Hospital of Sick Children, University of Toronto, Toronto, Canada, 5Merheim Medical Cent...
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ژورنال
عنوان ژورنال: Journal of the American Society of Nephrology
سال: 2009
ISSN: 1046-6673,1533-3450
DOI: 10.1681/asn.2009010123